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Date: 29-10-2020
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Aldol reactions are excellent methods for the synthesis of many enones or beta hydroxy carbonyls. Because of this, being able to predict when an aldol reaction might be used in a synthesis in an important skill. This accomplished by mentally breaking apart the target molecule and then considering what the starting materials might be.
Fragments which are easily made by an aldol reaction
Steps to 'reverse' the aldol reaction (from the final aldol product towards identifying the starting compounds).
1) From an enone break the double bond and form two single bonds. Place and OH on the bond furthest from the carbonyl and an H on the bond closest to the carbonyl.
2) From the aldol product break the C-C bond between the alpha carbon and the carbon attached to the OH. Then turn the OH into a carbonyl and add an hydrogen to the other carbon.
Example 1
What reactant must be used to make the following molecule using an aldol condensation?
SOLUTION
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تفوقت في الاختبار على الجميع.. فاكهة "خارقة" في عالم التغذية
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أمين عام أوبك: النفط الخام والغاز الطبيعي "هبة من الله"
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قسم شؤون المعارف ينظم دورة عن آليات عمل الفهارس الفنية للموسوعات والكتب لملاكاته
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