Radical Reactions

Radical reactions are not as common as polar reactions but are nevertheless important in some industrial processes and biological pathways. Let’s see briefly how they occur.

A radical is highly reactive because it contains an atom with an odd number of electrons (usually seven) in its valence shell, rather than a stable, noblegas octet. A radical can achieve a valence-shell octet in several ways. For example, the radical might abstract an atom and one bonding electron from another reactant, leaving behind a new radical. The net result is a radical substitution reaction.

Alternatively, a reactant radical might add to a double bond, taking one electron from the double bond and yielding a new radical. The net result is a radical addition reaction.

An example of an industrially useful radical reaction is the chlorination of methane to yield chloromethane. This substitution reaction is the first step in the preparation of the solvents dichloromethane (CH₂Cl₂) and chloroform (CHCl₃).

Like many radical reactions in the laboratory, methane chlorination requires three kinds of steps: initiation, propagation, and termination.

Initiation Irradiation with ultraviolet light begins the reaction by breaking

the relatively weak Cl-Cl bond of a small number of Cl₂ molecules to give a few reactive chlorine radicals.

Propagation Once produced, a reactive chlorine radical collides with a methane molecule in a propagation step, abstracting a hydrogen atom to give HCl and a methyl radical (·CH₃). This methyl radical reacts further with Cl₂ in a second propagation step to give the product chloromethane plus a new chlorine radical, which cycles back and repeats the first propagation step. Thus, once the sequence has been initiated, it becomes a selfsustaining cycle of repeating steps (a) and (b), making the overall process a chain reaction.

Termination Occasionally, two radicals might collide and combine to form a stable product. When that happens, the reaction cycle is broken and the chain is ended. Such termination steps occur infrequently, however, because the concentration of radicals in the reaction at any given moment is very small. Thus, the likelihood that two radicals will collide is also small.