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Date: 16-5-2017
1772
Date: 24-11-2019
768
Date: 10-9-2020
1537
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As previously seen, aldehydes and ketones react with 2o amines to reversibly form enamines.
Example
Reversible
Enamines act as nucleophiles in a fashion similar to enolates. Because of this enamines can be used as synthetic equivalents as enolates in many reactions. This process requires a three steps: 1) Formation of the enamine, 2) Reaction with an eletrophile to form an iminium salt, 3) Hydrolysis of the iminium salt to reform the aldehyde or ketone. Some of the advantages of using an enamine over and enolate are enamines are neutral, easier to prepare, and usually prevent the overreaction problems plagued by enolates. These reactions are generally known as the Stork enamine reaction after Gilbert Stork of Columbia University who originated the work.
Typically we use the following 2o amines for enamine reactions
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علامات بسيطة في جسدك قد تنذر بمرض "قاتل"
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أول صور ثلاثية الأبعاد للغدة الزعترية البشرية
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مكتبة أمّ البنين النسويّة تصدر العدد 212 من مجلّة رياض الزهراء (عليها السلام)
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