The Michael Reaction-Basic reaction of 1,4 addition
المؤلف:
..................
المصدر:
LibreTexts Project
الجزء والصفحة:
.................
25-11-2019
1446
The Michael Reaction-Basic reaction of 1,4 addition
In 1,4 addition the Nucleophile is added to the carbon β to the carbonyl while the hydrogen is added to the carbon α to the carbonyl.
Mechanism for 1,4 addition
1) Nucleophilic attack on the carbon β to the carbonyl
2) Proton Transfer
Here we can see why this addition is called 1,4. The nucleophile bonds to the carbon in the one position and the hydrogen adds to the oxygen in the four position.
3) Tautomerization
Enolates undergo 1,4 addition to α, β-unsaturated carbonyl compounds is a process called a Michael addition. The reaction is named after American chemist Arthur Michael (1853-1942).
الاكثر قراءة في مواضيع عامة في الكيمياء العضوية
اخر الاخبار
اخبار العتبة العباسية المقدسة
