Hydroperoxidases play an important role in protecting the body against the harmful effects of reactive oxygen species (ROS). ROS are highly reactive oxygen-containing molecules such as peroxides, which are formed during normal metabolism, but can be damaging if they accumulate. They are believed to contribute to the causation of diseases such as cancer and atherosclerosis, as well as the aging process in general.

Peroxidases Reduce Peroxides Using Various Electron Acceptors

 Peroxidases are found in milk as well as in leukocytes, plate lets, and other tissues involved in eicosanoid metabolism . Their prosthetic group is protoheme. In the reaction catalyzed by peroxidase, hydrogen peroxide is reduced at the expense of several substances that act as electron acceptors, such as ascorbate (vitamin C), quinones, and cytochrome c. The reaction catalyzed by peroxidase is complex, but the overall reaction is as follows:

In erythrocytes and other tissues, the enzymeglutathione peroxidase, containing selenium as a prosthetic group, catalyzes the destruction of H₂O₂ and lipid hydroperoxides through the conversion of reduced glutathione to its oxidized form, protecting membrane lipids and hemoglobin against oxidation by peroxides .

Catalase Uses Hydrogen Peroxide as Electron Donor & Electron Acceptor

Catalase is a hemoprotein containing four heme groups. It can act as a peroxidase, catalyzing reactions of the type shown earlier, but it is also able to catalyze the breakdown of H₂O₂ formed by the action of oxygenases to water and oxygen:

This reaction uses one molecule of H₂O₂ as a substrate electron donor and another molecule of H₂O₂ as an oxidant or electron acceptor. It is one of the fastest enzyme reactions known, destroying millions of potentially damaging H₂O₂ molecules per second. Under most conditions in vivo, the peroxidase activity of catalase seems to be favored. Catalase is found in blood, bone marrow, mucous membranes, kidney, and liver. Peroxisomes are membrane-bound organelles found in many tissues, including liver. They are rich in oxidases and in catalase. Thus, enzymes that produce and breakdown H₂O₂ are contained within the same subcellular compartment. However, mitochondrial and microsomal electron transport systems as well as xanthine oxidase must be considered as additional sources of H₂O₂ .

مواضيع ذات صلة

Oxygenases Catalyze The Direct Transfer & Incorporation of Oxygen Into A Substrate Molecule

اضطرابات استقلاب النوكليوتيدات البيريميدينية

اضطرابات استقلاب النكليوتيدات البورينية

تخليق النوكليوتيدات منقوصة الاكسجين ( dNTPs )

تقويض النوكليوتيدات البيريميدينية

Dehydrogenases Perform Two Main Functions

Oxidases Use Oxygen As A Hydrogen Acceptor

تخليق النكليوتيدات البيريميدينية

تقويض النوكليوتيدات البورينية

تنظيم استحداث البورينات

التخليق الحيوي للنوكليوتيدات البورينية

سبيل كيناز جانوس ومُنبِّغات الإشعار ومنشطات الانتساخ Jak/STATS Pathway