Coding Strand

 This is an ambiguous term, and perhaps best avoided. Because DNA is double-stranded and only one strand of the DNA of a gene is usually transcribed to make RNA, there is a distinction between the transcribed and the nontranscribed strand at any point in the genome. Using the useful terminology “upstream”/“downstream” to refer to the direction in which the gene is transcribed and translated, the nontranscribed DNA strand runs upstream to downstream in the chemical direction 5′ to 3′, whereas the complementary transcribed strand has the opposite 3′ to 5′ polarity. The transcript RNA runs 5′ to 3′, like the nontranscribed DNA strand. Thus, the nontranscribed DNA strand matches the mRNA in its base sequence (with thymine replacing uracil), not the transcribed strand which has the back-to-front complements of the codons, as explained in Figure 1. Consequently, in predicting encoded amino acid sequence of the encoded protein from a gene DNA sequence, one uses the sequence of the nontranscribed DNA strand because this is the strand from which the codons can be read directly. For this reason, the nontranscribed strand is sometimes called the coding strand.

Some workers, however, adopt the opposite convention because, after all, the transcribed strand provides the information for the codon sequence of the mRNA. Therefore, it is best to eschew the coding versus noncoding terminology and to distinguish the two DNA strands as transcribed versus nontranscribed.

It should be remembered that both strands of a particular segment of DNA can be transcribed, though probably never in the same cell type and at the same time. This may be the case, for example, when genes are “nested” within the introns of other genes  .

اخر الاخبار

اخبار العتبة العباسية المقدسة

قسم الشؤون الدينية يوزع أكثر من ألفي وجبة طعام للمعزين في ذكرى عاشوراء بنينوى

قسم الشؤون الطبية يواصل تقديم خدماته الصحية لزائري عاشوراء

جموع المعزين تحيي مراسم يوم العاشر من شهر المحرم عند المرقدين الطاهرين

قسم العلاقات يطلق محطات فتية الكفيل الثقافية في محافظة نينوى

المزيد

الآخبار الصحية

لهذا السبب.. إغلاق 25 مركزًا لعلاج الإدمان في مصر ؟

خلافا للاعتقاد الشائع.. علماء يكشفون أسرار بذور البطيخ ؟!

هذا ما يحدث لجسمك عند تناولك الطماطم بانتظام !

تعرف على أطعمة تسرّع "تعافي الجسم" من حروق الشمس

المزيد

الآخبار التكنلوجية

الثلوج تغطي الصحراء الأكثر جفافا في العالم!

بتلسكوب "ألما".. التقاط صورا غير مسبوقة لبدايات الكون !

هل هاتفك مراقب؟.. 5 علامات خطيرة تكشف التجسس عليك

دبي تطلق أول رحلة تجريبية للتاكسي الجوي

المزيد

مواضيع ذات صلة

Genotoxicity Through Potential Off-target Nuclease - Induced Double - Strand Breaks

A Broad Range of Genomic Changes by Homologous Recombination–Mediated Genome Editing

Early Transcription of Genes N and Cro

Lambda’s Relatives and Lambda Hybrids

The Genetic Structure of Lambda

The Physical Structure of Lambda

Other Attenuated Systems: Operons, Bacillus subtilis and HIV

Coupling Translation to Termination

trp Multiple Secondary Structures in trp Leader RNA

Early Explorations of the Hypersynthesis

The Serendipitous Discovery of trp Enzyme Hypersynthesis

Rapid Induction Capabilities of the trp Operon