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Mifepristone (RU-486)

المؤلف:  Norman, A. W., & Henry, H. L.

المصدر:  Hormones

الجزء والصفحة:  3rd edition , p236

2026-08-27

170

RU-486 is used widely around the world as an abortifacient in less than 49 days of pregnancy. As discussed in Figure 1, progesterone must be present in nor mal concentrations to maintain the pregnancy. RU-486 is an antagonist of the progesterone receptor and its presence can initiate the beginning of an abortion. It works by interfering with the supply of hormones that maintains the interior of the uterus. Millions of women worldwide have safely used mifepristone (RU-486). The use of RU-486 has been officially approved in 29 countries, including the USA.

Fig1. Progesterone and related compounds. A. Progesterone is the only naturally occurring ligand for the progesterone receptor. B. Many antagonistic ligands for the progesterone receptor have been synthesized of which two are illustrated.

Mifepristone is also used clinically to control high blood sugar in patients with Cushing’s syndrome and who also have type 2 diabetes and have failed surgery or are not candidates for surgery.