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DISTRIBUTION

المؤلف:  Max M. Houck، Jay A. Siegel

المصدر:  Fundamentals of Forensic Science

الجزء والصفحة:  357

2026-08-10

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DISTRIBUTION

Blood reaches every cell in the body and drugs are distributed via the bloodstream. Some portion of a given drug may be bound to blood proteins and would be unavailable for interacting with the brain or other organs and this must be taken into account when determining the effective concentration of a drug. Although a drug in the bloodstream will reach all tissues in the body, this doesn’t mean that the concentration of the drug is the same everywhere. Some organs, such as the brain, heart, and liver receive more of a blood supply than less vital organs so they would be exposed to more of a given drug. Also many drugs have a chemical structure that causes them to preferentially collect in particular types of tissue. For example, some pesticides tend to be attracted to adipose (fatty) tissue. Once the tissue absorbs these drugs, they are very hard to remove. Over time, large concentrations can build up. This can cause great harm or even death. If pesticides are dumped into lakes and rivers and fish ingest them, the pesticides will collect in the fatty tissues of the fish. When humans eat the fish, large doses of the pesticides can be transferred to them.