تسجيل الدخول

تسجيل

Nocardia, Streptomyces, Rhodococcus, and Similar Organisms: Antimicrobial Susceptibility Testing and Therapy

المؤلف:  Patricia M. Tille, PhD, MLS(ASCP)

المصدر:  Bailey & Scotts Diagnostic Microbiology

الجزء والصفحة:  13th Edition , p304-305

2026-05-11

499

A standard for susceptibility testing by broth microdilution and with cation-supplemented Mueller-Hinton broth has been approved by the Clinical and Laboratory Standards Institute (CLISI; formerly the National Committee for Clinical and Laboratory Standards), along with interpretive guidelines. Other methods, including modified disk diffusion, agar dilution, broth microdilution, E-test, and radiometric growth index have been used for antimicrobial susceptibility testing of Nocardia spp. However, although these methods demonstrate good interlaboratory and intralaboratory agreement and reproducibility, correlation of in vitro susceptibility testing results with clinical outcome has not been systematically performed at the time of this writing. Nevertheless, antimicrobial susceptibility testing should be performed on clinically significant isolates of Nocardia spp. If required, the isolate should be sent to a reference laboratory. For all other actinomycetes, no standardized methods currently are available. In some instances, susceptibility studies of Rhodococcus and Gordonia spp. can be used as a guide for directing therapy.

The primary drugs of choice against the aerobic actinomycetes are shown in Table 1; no effective antimicrobial therapy is available for hypersensitivity pneumonitis caused by the thermophilic actinomycetes.

Table1. Primary Drugs of Choice for Infections Caused by Aerobic Actinomycetes