Type of test Blood; urine (24-hour); cerebrospinal fluid (CSF) analysis

Normal findings

 Serum Adult/elderly: 15-36 mg/dL or 150-360 mg/L (SI units)

 Child

- < 5 days: 6-21 mg/dL

- 1-5 years: 14-30 mg/dL

- 6-9 years: 15-33 mg/dL

- 10-13 years: 22-36 mg/dL

- 14-19 years: 22-45 mg/dL

Urine (24-hour) : 0.017-0.047 mg/day

CSF: Approximately 2% of total CSF protein

Possible critical values: Serum prealbumin levels less than 10.7 mg/dL indicate severe nutritional deficiency.

Test explanation and related physiology

 Prealbumin is one of the major plasma proteins. Because pre albumin can bind thyroxine, it is also called thyroxine- binding prealbumin (TBA). However, prealbumin is secondary to thyroxine-binding globulin in the transportation of triiodothyronine (T3) and thyroxine (T4). Prealbumin also plays a role in the transport and metabolism of vitamin A.

Because prealbumin levels in serum fluctuate more rapidly in response to alterations in synthetic rate than do those of other serum proteins, clinical interest in the quantification of serum prealbumin has centered on its usefulness as a marker of nutritional status. Its half-life of 1.9 days is much less than the 21-day half-life of albumin. Because prealbumin has a short half-life, it is a sensitive indicator of any change affecting protein synthesis and catabolism. For this reason, prealbumin is frequently ordered to monitor the effectiveness of total parenteral nutrition (TPN).

Prealbumin is significantly reduced in hepatobiliary disease because of impaired synthesis. Prealbumin is also a negative acute phase reactant protein; serum levels decrease in inflammation, malignancy, and protein-wasting diseases of the intestines or kidneys. Because zinc is required for synthesis of prealbumin, low levels occur with a zinc deficiency. Increased levels of prealbumin occur in Hodgkin disease and chronic kidney disease.

 Interfering factors

 • Coexistent inflammation may make the interpretation of test results impossible.

* Drugs that may cause increased levels include anabolic steroids, androgens, and prednisolone.

* Drugs that may cause decreased levels include amiodarone, estrogens, and oral contraceptives.

 Procedure and patient care

 • See inside front cover for Routine Blood Testing.

 • Fasting: no

• Blood tube commonly used: red

• If the patient is going to collect a 24-hour urine specimen, provide a collection bottle. (See guidelines on inside front cover.)

 Abnormal findings

Increased levels

- Some cases of nephrotic syndrome

- Hodgkin disease

- Chronic kidney disease

- Pregnancy

Decreased levels

- Malnutrition

- Liver damage

- Burns

- Salicylate poisoning

- Inflammation

- Infection

اخر الاخبار

اخبار العتبة العباسية المقدسة

أكاديمية التطوير الإداري تنظّم دورة في اللغة الفارسية لعدد من ملاكات العتبة العباسية المقدسة

استعدادًا لافتتاحه.. المشرف على قسم الشؤون الطبية يجري جولة في مركز السيد جعفر الحلي للخدمات الطبية.

الهيأة العليا لإحياء التراث تقيم الدورة العلمية التخصصية لكتاب في رحاب العقيدة

سماحة السيد الصافي يؤكد ضرورة تنمية الموارد المالية لدائرة التقاعد الوطنية وتعظيمها

المزيد

الآخبار الصحية

العلاج بالماء البارد.. باحثون يكشفون فوائده الصحية

من دون صالة رياضية.. عادة بسيطة لتحسين الصحة وخسارة الوزن

لصحة القلب وتفادي السرطان.. استهلك هذا النوع من الطعام

دراسة تحذر من خطر شرب القهوة في أكواب البلاستيك

المزيد

الآخبار التكنلوجية

إنجاز طبي تاريخي.. جراحة قلب بلا شق في الصدر

اليابان.. مراحيض توفر فحص للحالة الصحية عبر "تحليل البراز" !

اختراق واسع لمنصة "إنستغرام".. ونشر بيانات على "الدارك ويب"

علماء يحذرون: هكذا سيفنى كوكب الأرض

المزيد

مواضيع ذات صلة

ProstaScint scan (Radioimmunoscintigraphy of the prostate [RIS])

pregnanediol

Biomarkers of Sepsis

Role of the Laboratory in Sepsis

potassium, urine (K)

porphyrins and porphobilinogens

platelet function assay (Platelet closure time, PCT, Aspirin resistance tests, Bleeding time [BT], 11-Dehydro-thromboxane B2)

Laboratory Diagnosis of Rabies Virus

Procalcitonin

Erythrocyte Sedimentation Rate

C-Reactive Protein

plasminogen (Fibrinolysin)