Type of test Blood

 Normal findings

 Negative; no agglutination

Test explanation and related physiology

 The indirect Coombs test detects circulating antibodies against RBCs. The major purpose of this test is to determine whether the patient has minor serum antibodies (other than the major ABO/Rh system) to RBCs that he or she is about to receive by blood transfusion. Therefore this test is the screening part of the type and screen routinely performed for blood compatibility testing (cross-matching in the blood bank).

Unlike the direct Coombs test that is performed on the patient’s RBCs, this test is performed on the patient’s serum. In this test, a small amount of the recipient’s serum is added to donor RBCs containing known antigens on their surfaces. This is the first stage. In the second stage of the test, Coombs serum is added. If antibodies exist in the patient’s serum, agglutination occurs. In blood transfusion screening, visible agglutination indicates that the recipient has antibodies to the donor’s RBCs. If the recipient has no antibodies against the donor’s RBCs, agglutination will not occur; transfusion should then proceed safely and without any transfusion reaction.

Interfering factors

* Drugs that may cause false-positive results include antiarrhythmics, antituberculins, cephalosporins, chlorpromazine, insulin, levodopa, methyldopa, penicillin, phenytoin, quinidine, sulfonamides, and tetracyclines.

 Procedure and patient care

 • See inside front cover for Routine Blood Testing.

• Fasting: no

 • Blood tube commonly used: red

 Abnormal findings

- Incompatible cross-matched blood

- Maternal anti-Rh antibodies

- Hemolytic disease of the newborn

- Acquired immune hemolytic anemia

- Presence of specific cold agglutinin antibody

اخر الاخبار

اخبار العتبة العباسية المقدسة

بيان صادر عن العتبة العباسية المقدسة

قسم التطوير يقيم دورة تدريبية عن الهندسة النفسية لملاكاته

تضررت في الانتفاضة الشعبانية.. الكشف عن قطع تاريخية من الإيوان الذهبي لمرقد أبي الفضل العباس (عليه السلام)

قسم الصناعات ينهي أعمال صيانة منظومة التهوية في مجمع أبي الفضل العباس (عليه السلام)

المزيد

الآخبار الصحية

عادات يومية تدمر قلبك بصمت.. خبراء يطلقون التحذير

خبراء تغذية يكشفون "أفضل وقت لتناول الإفطار"

أطعمة تزيد فرص وفاة مرضى السرطان 60 بالمئة.. ما هي؟

اختبار ثوري جديد يكشف مبكرا عن سرطان البنكرياس

المزيد

الآخبار التكنلوجية

الذكور أم الإناث؟ دراسة "تنسف الشائع" بشأن التوحد

خبير يكشف عن اقتراب العلماء من فك شفرات "لغات الحيوانات" !

دراسة تدفعك لشراء ساعة ذكية "فورا".. هذا ما تقوله عن قلبك

علماء حاصلون على "نوبل": الذكاء الاصطناعي لن يستبدل الإنسان

المزيد

مواضيع ذات صلة

tuberculosis testing (TB testing, Interferon gamma release assay [IGRA, T-Spot.TB], QuantiFERON-TB Gold [QFT, QFT-G, TB Gold test, TB blood test], Nucleic acid amplification for TB [NAAT], TB antibody)

thyrotropin-releasing hormone stimulation test (TRH stimulation test, Thyrotropin-releasing factor stimulation test [TRF stimulation test])

Laboratory Diagnosis of Lower Respiratory Tract Infections: Specimen Processing

Laboratory Diagnosis of Lower Respiratory Tract Infections: Specimen Collection and Transport

thyroid scanning (Thyroid scintiscan)

thyroid fine needle aspiration biopsy (FNAB, Skinny needle thyroid biopsy, Fine-needle aspiration [FNA])

thoracentesis and pleural fluid analysis (Pleural tap)

The Role of Laboratory in Urgency: Altered State of Consciousness

Preoperative Laboratory Test

sputum culture and sensitivity (C&S, Culture and Gram stain)

sodium (Na), blood

small intestinal bacterial overgrowth test (SIBO test, Lactulose Breath Test)