progesterone assay
المؤلف:
Kathleen Deska Pagana, Timothy J. Pagana, Theresa Noel Pagana.
المصدر:
Mosbys diagnostic and laboratory test reference
الجزء والصفحة:
15th edition , p730-731
2025-08-11
446
Type of test Blood
Normal findings
< 9 years: < 20 ng/dL
10-15 years: < 20 ng/dL
Adult male: 10-50 ng/dL
Adult female Follicular phase: < 50 ng/dL Luteal: 300-2500 ng/dL
Postmenopausal: < 40 ng/dL
Pregnancy: First trimester: 725-4400 ng/dL Second trimester: 1950-8250 ng/dL Third trimester: 6500-22,900 ng/dL
Test explanation and related physiology
The major effect of progesterone is to induce the development of the secretory phase of the endometrium in anticipation of implantation of a fertilized ovum. Normally, progesterone is secreted by the ovarian corpus luteum after ovulation. Serum progesterone level is significantly increased during the second half of the ovulatory cycle. Normally, blood samples drawn at days 8 and 21 of the menstrual cycle show a large increase in progesterone levels in the latter specimen, indicating that ovulation has occurred. Therefore this study is useful in documenting whether ovulation has occurred and, if so, its exact time. This is very useful information for a woman who has difficulty becoming pregnant.
In pregnancy, progesterone is produced by the corpus luteum for the first few weeks. After that, the placenta begins to make progesterone. Progesterone levels should progressively rise during pregnancy because of placental production. Repeated assays can be used to monitor the status of the placenta in cases of high risk pregnancy. Progesterone assay is also used today to monitor progesterone supplementation in patients with an inadequate luteal phase to maintain an early pregnancy.
Interfering factors
• Hemolysis caused by rough handling of the sample may affect test results.
* Drugs that may interfere with test results include clomiphene, estrogen, and progesterone.
Procedure and patient care
• See inside front cover for Routine Blood Testing.
• Fasting: no
• Blood tube commonly used: red
• Indicate the date of the last menstrual period on the laboratory slip.
Abnormal findings
Increased levels
-Ovulation
- Pregnancy
- Luteal cysts of ovary
- Hyperadrenocorticalism
- Adrenocortical hyperplasia
- Choriocarcinoma of ovary
- Hydatidiform mole of the uterus
Decreased levels
-Preeclampsia
- Toxemia of pregnancy
-Threatened abortion
- Placental failure
- Fetal death
- Ovarian neoplasm
- Amenorrhea
- Ovarian hypofunction
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